Flow Chemistry Congress 2021 Agenda

Conference Registration, Coffee and Danish Breakfast

Welcome Address: Ferenc Darvas, Chairman, Flow Chemistry Society

Tim Noel, Associate Professor, Eindhoven University of Technology
Innovation in Synthetic Methodology Development Through Flow Chemistry
In this presentation, we will give a selection of our synthetic methodology development, exemplified by photoredox catalysis, C–H activation chemistry and electrochemistry and how these synthetic methods were impacted by continuous-flow microreactor technology.

Shawn Collins, Professor, University of Montreal
Photochemical Macrocyclization in Flow
Efforts to render photochemical macrocyclization a pratical and useful technique for the synthesis of large ring compounds will be discussed. Through the combination of new chemistry and continuous flow techniques, the goal of continuous synthesis of macrocycles on gram scale can be achieved.

Networking with Exhibitors and Coffee

Matt Beaver, Senior Scientist, Amgen
The Convergence of New Chemical Methods and Advanced Engineering Principles: The Case for Continuous Manufacturing
Presented herein are case studies where the implementation of continuous manufacturing significantly improved, or simply made possible, the production-scale synthesis of chemical matter across Amgen’s synthetic portfolio.

Anne-Catherine Bedard, Senior Chemist, Chemical Science, Core R&D, Dow Chemical
Reconfigurable System for Automated Optimization of Diverse Chemical Reactions
Chemical synthesis generally requires labor-intensive, sometimes tedious trial-and-error optimization of reaction conditions. Here, we describe a plug-and-play, continuous-flow chemical synthesis system that mitigates this challenge with an integrated combination of hardware, software, and analytics.

Networking with Exhibitors and Lunch

Tim Jamison, Professor, MIT
On-Demand Synthesis:  The When, How, and Why of Flow Chemistry
Flow chemistry has the potential to revolutionize the synthesis of organic molecules.  Flow systems can reduce reaction times, increase efficiency, and obviate problems often encountered in scaling up comparable batch processes.  In addition to these important practical advantages, flow chemistry expands the “toolbox” of organic reactions available to scientists engaged in the synthesis of molecules – from small-scale experiments to large-scale production.  These benefits are a direct result of several features of flow synthesis that batch synthesis typically cannot achieve, for example, the ability to control fluid flow precisely, the access to temperature and pressure regimes not usually considered to be practical, and the enhanced safety characteristics of flow chemical systems.  In this lecture we will discuss some of our investigations in this area in the form of case studies.  By enhancing the design rules for organic synthesis and molecular discovery, flow chemistry therefore represents an important conceptual advance in the design and execution of chemical syntheses.  On-demand synthesis embodies these and other exciting opportunities.

Andre Charette, Professor, University of Montreal
Using Continuous Flow Synthesis to Solve Problems in Total Synthesis and in Methodology Development
This talk will illustrate by several examples, how useful continuous flow synthesis is for solving daily problems that are encountered in a synthetic organic chemistry laboratory.

Emily Corcoran, Researcher, Merck
Developing a Strategy for Scaling Photoredox Chemistry in Flow
This presentation highlights efforts within the flow chemistry group at MRL to define an approach to scale up photoredox reactions using continuous flow. The elucidation of an empirical scaling factor by studying the performance of a photoredox cross-coupling reaction will be discussed.

Networking with Exhibitors and Coffee

Nathan Collins, Chief Strategy Officer, SRI International
Accelerating the rate of chemistry innovation through automated flow synthesisExamples of how SynFini is used in the synthesis of diverse and increasing complex molecules, as well as applications in novel molecular discovery will be presented.

Amanda Evans, Scientist, Livermore National Lab
Continuous Biocatalytic/Chiroptical Manufacturing Approaches for Making Useful Molecules
Novel asymmetric continuous manufacturing approaches for producing products essential to industry will be discussed.

Speaker to be Confirmed
Title to be confirmed

Poster Party

Close of Day 1

Conference Registration, Coffee and Danish

Klavs Jensen, Professor, MIT
Integrating of Machine Learning, Automation, and Flow Chemistry
Flow chemistry in a robot configured system and droplet-screening systems exemplify advances in machine learning, automation and experimental techniques for optimization of flow chemistry processes. 

Adrian Amador, Scientist, Snapdragon Chemistry

Efficient Optimization and Predictable Scaling of Photochemical Reactions Using Modern Technologies
Over the last decade there has been a rapid growth in new photochemical transformations using both direct substrate irradiation and photocatalysis. Many of these transformations have added enabling bond disconnections that were otherwise not possible using thermal reaction pathways. Due to limitations of light penetration into batch reaction vessels, flow chemistry has proven vital in the scaling of these types of reactions. Developing a structured and efficient approach to the optimization of these reactions on lab scale and being able to predict the scaling of the chemistry to larger scale photoreactors will allow a critical path for process development. This presentation will highlight the efforts at Snapdragon Chemistry, Inc. to develop an efficient approach in developing scalable photochemical processes. Our approach leverages custom reactor design, modern automated workflows, as well as mechanistic and statistical modeling to gain key process insights required during lab scale development. Several case studies will be presented which show the use of these technologies for the rapid optimization and predictive scaling of the process.

Allan Meyerson, Professor, MIT
Continuous Crystallization of Pharmaceuticals

Coffee and Networking with Exhibitors

Speaker to be Confirmed 
Title to be Confirmed

Nick Thompson, Senior Director, Pfizer
Flexible API Supply Technologies; Pfizer’s Strategy for Small Molecule API Continuous Development and Manufacturing
The talk will outline Pfizer’s strategy for continuous development and manufacturing of small molecule active pharmaceutical ingredients, including the business case, portfolio focus and development of facilities and modular technologies.

Sal Mascia, Founder and CEO, CONTINUUS Pharmaceuticals
Compact Factory for Integrated Continuous Manufacturing (ICM) of API and DP Operations
A compact factory that integrated chemical operation and formulation in one seamless continuous manufacturing process is being presented. The automation and integration aspects together with the use of novel technologies are key enablers for end-to-end continuous production of pharmaceuticals.

Lunch and Networking with Exhibitors

Jana Stoudemire, Commercial Innovation Officer, Space Tango
Establishing Flow Chemistry Capabilities for Production of Pharmaceutical and Chemical Products in Microgravity
A discussion of the ISS-NL and Boston University (The Beeler Group) current ISS payload included on the SpaceX 20th Commercial Resupply Mission (SpaceX CRS-20) scheduled to launch on March 2nd, and The University of Adelaide long-duration stability studies scheduled to launch later this year will be provided, along with an overview of continued plans for future development.

Danielle Wood, Assistant Professor, MIT
Title to be Confirmed

Aaron Beeler, Professor, Boston University
Title to be Confirmed

Jason Williams, Senior Postdoc, University of Graz
Intensification of Flow Photochemistry towards Industrial Scale Processing
Our efforts towards improved scale-up of flow photochemical processes will be presented. This includes strategies for process intensification, for faster reactions, higher throughputs and improved sustainability.

Close of Conference